The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.
Responsibilities:
- Lead the siRNA synthesis platform to support various stages of siRNA studies.
- Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
- Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
- Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
- Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
- Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
- Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
- Mentor junior scientists and contribute to a collaborative, high-performing team environment.