Union: Non-Union
Number of Vacancies: 1
New or Replacement Position: New
Site: Princess Margaret Cancer Centre
Department: Research
Reports to: Principal Investigator
Salary Range: $68,932 - $103,409 Annually
Hours: 37.5 Hours Per Week
Shifts: Monday - Friday, Days
Status: Temporary Full-time
Closing Date: March 13, 2026
Position Summary:
A Senior Bioinformatics Analyst position is available in Toronto, Canada, in the laboratories of Dr. Tomohiro Aoki and Dr. Robert Vanner at the Princess Margaret Cancer Centre, University Health Network; one of the top five cancer research centers in the world. The research focus is basic/translational research in cancer immunology and cancer genomic field in the lymphoid malignancy and clonal hematopoiesis. With access to our world-class computational infrastructure, and in collaboration with world-leading scientists locally and abroad, the successful candidate will help organize, plan, analyze, and interpret the results from a variety of exciting large genomic cohort analyses that are currently ongoing.
Duties:
- Design and execute experiments to study the pathogenesis, molecular mechanism and treatment resistance mechanism, and tumor-microenvironment interaction in lymphoid malignancy
- Analyze and interpret molecular analyses from DNA/RNA sequencing data (including single cell sequencing, whole genome sequencing, circulation tumor DNA analyses, methylation profiling)
- Analyze and interpret spatial analyses (e.g. protein level and transcriptional level)
- Develop and oversee high-throughput data pipelines, including data from many new single-cell technologies such as scRNA-seq, scATAC-seq, scMultiome-seq, and Visium/CosMx spatial transcriptomics.
- Analyze any sequencing data using established pipelines.
- Develop new computational methods to integrate and interpret multi-omics data.
- Assist and collaborate with internal and external researchers in interpretation of sequencing data.
- Contribute to the codebase, development, and support of open-source software packages.
- Help to manage lab servers and computational infrastructure.
- Document and present results in written or oral reports to other lab members.
- Work collaboratively with other research team members and external collaborators.
- Participate in multidisciplinary projects combining biochemistry, structural biology, and computational methods
- Stay updated with the latest research in cancer genomics, cancer immunology and lymphoma biology.
- Review and summarize relevant scientific literature to inform experimental design and data interpretation
- Prepare manuscripts for publication in scientific journals
- Present research findings at national and international conferences, seminars, and workshops
- Assist in writing grant proposals to secure funding for ongoing and future research projects.
- Mentor and supervise graduate and undergraduate students involved in related research projects
- Provide guidance on experimental techniques and data analysis