The Checkpoint Immunology group is seeking an experienced Principal Research Scientist I to advance novel immune checkpoint programs for autoimmune and inflammatory diseases. The successful candidate will provide scientific leadership across discovery and translational research activities, driving innovative therapeutic concepts from target identification through candidate nomination.
This role is ideal for a scientist who combines deep immunology expertise with a strong drug discovery mindset, enjoys solving challenging biological questions in emerging areas of science, and thrives in a collaborative, cross-functional environment.
Responsibilities
- Lead the scientific strategy and execution of one or more discovery-stage immunology programs.
- Drive biological understanding of novel immune regulatory pathways and translate insights into therapeutic opportunities.
- Lead from the bench by designing, executing, and interpreting critical experiments while mentoring other scientists.
- Build scientific capability within the team and foster a strong drug discovery mindset
- Integrate biology, pharmacology, translational sciences, and external collaborations to advance program objectives.
- Coordinate cross-functional workflows and drive alignment across multidisciplinary teams.
- Ensure high-quality project planning through sound experimental design, early risk assessment and robust contingency planning through integrated timelines
- Contribute to PK/PD, translational, and biomarker strategies that support candidate selection and development decisions.
- Foster a collaborative, high-performing team culture through mentorship, scientific rigor, and effective teamwork.