As a China Precision Medicine Lead - Oncology, he/she will have the opportunity to work in a fast-paced and highly collaborative environment to lead the development and execution of Precision Medicine strategies for Oncology programs in early/late-stage clinical development. The successful candidate will work with global Precision Medicine Team responsible for development and execution of translational research and clinical biomarker strategies (predictive/pharmacodynamic/resistance biomarkers, molecular response endpoints, indication selection and combination strategies) in alignment with the overall asset strategy, and ensuring successful execution of drug-diagnostic co-development in collaboration with the Companion Diagnostics group within Precision Medicine. This role requires an exceptional translational scientist with outstanding communication and leadership skills to drive effective decisions with key cross-functional stakeholders and enable execution of the overall Precision Medicine strategy for the program.
Primary Responsibilities:
- Lead the development, and execution of the overall Precision Medicine strategy for one or more AbbVie China Oncology programs, in partnership with global Precision Medicine strategy team
- Design and implement hypothesis-driven strategies to deliver evidence of target engagement, mechanisms of action/resistance, patient selection/CDx strategies (in partnership with CDx Lead), and other clinically relevant biomarker endpoints to advance the AbbVie Oncology pipeline
- Enable cross functional collaboration on the Precision Medicine strategy, leading the design, execution, analysis, communication, and publication of translational research and correlative clinical biomarker studies
- Review and refine Precision Medicine related sections in clinical study / regulatory documents (i.e. INDs, IBs, trial protocols/ops manuals, ICFs, IRB responses, HGRAC application dossier, HA Briefing Books, CSRs, etc)
- Be accountable for the overall China Precision Medicine strategy in oncology clinical studies, in compliance with AbbVie’s processes and regulatory requirements
- Provide oversight of external collaborations (academic/industry/consortia) that advance the overall Precision Medicine objectives for the program
- Prepare and present Precision Medicine deliverables to governance bodies, review forums, decision committees and project teams
- Represent Precision Medicine function at advisory boards and health authority interactions to advance translational research and clinical biomarker objectives for the program
- Drive scientific and/or technical innovation collaboratively with other members of Precision Medicine Oncology