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Job Summary
Summary
Qualifications
Education
Doctorate Related Field of Study required
Can this role accept experience in lieu of a degree?
No
Licenses and Credentials
Experience
Previous Research experience 3-5 years required
Knowledge, Skills and Abilities
- Demonstrated experience in research techniques, methods, or research areas relevant to the project.
- Proficient analytical skills, proficiency in statistical software, and excellent written and verbal communication skills.
- Ability to work independently as well as collaboratively within a team.
- Good interpersonal and communication skills.
Salary: $71,750.00 - $73,544.00/Annual
Additional Job Details (if applicable)
POSITION SUMMARY:
Postdoctoral Fellow – Drug Discovery, Molecular Biology & Biochemistry
The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery.
Please reach out to Sophia_shalhout@meei.harvard.edu for further information and any questions.
ESSENTIAL FUNCTIONS:
· Design and perform biophysical and biochemical assays, including protein purification, binding/interaction studies, cell reporter assays, and enzymatic assays. Purify and characterize proteins for structural and functional studies.
· Design and perform protein–protein and protein–ligand interactions (e.g., SPR, ITC, pull-downs, FRET).
· Conduct cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways.
· Carry out molecular biology techniques, including cloning, mutagenesis, and protein expression. Perform mutagenesis and structure–function studies to map binding sites and mechanisms of action.
· Support hit validation and lead optimization through iterative testing of small molecules.
· Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design.
· Basic understanding of biostatistics
· Analyze and interpret experimental data, present findings in lab meetings, publications, and conferences.
· Collaborate with team members on projects linking experimental data to translational cancer research
EDUCATION AND EXPERIENCE:
MD or PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery, small-molecule therapeutics, or translational oncology research.
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
EEO Statement:
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
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