Scientist II, In Vivo Pharmacology

Our expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives

The successful candidate will have expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice. Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential.

Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.

Core Responsibilities:

• Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
• Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.
• Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
• Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets.
• Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.
• Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques.
• Appetite for developing novel in vivo approaches and models to address complex biological questions.