The position will support a Neuroscience Biomarks client team that is responsible for LC-MS-based proteomics to identify and quantify biomarkers associated with neurodegenerative diseases, including Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. We are looking for a motivated scientist eager to gain hands-on experience in LC-MS proteomics workflows applied to CSF, plasma, and tissue biomarker studies, and to grow their technical skills in a collaborative, fast-moving research environment. Principal responsibilities will include weekly and monthly lab operations tasks (approximately 70% effort) while additional responsibilities will include routine testing (approximately 30% effort).
Job Responsibilities and Requirements
Lab Operations:
- Manage lab instruments, consumables, and chemicals/reagents.
- Manage lab supply and reagent inventory, including aliquoting, ordering, and stocking.
- Perform sample management, including sorting, storage, and manifest recording in Benchling (ELN).
- Prepare reagents and solutions for proteomics and biochemistry workflows.
- Coordinate with the facilities team to manage instrument servicing and preventive maintenance schedules.
Analytical Testing:
- Perform biochemistry assays, including sample preparation and Western Blotting using human or animal biospecimen.
- Perform LC-MS support tasks including instrument source cleaning, monthly QC runs, mobile phase and buffer preparation, and sample injection on Thermo Orbitrap and Sciex triple quadrupole platforms.
- Process and analyze data generated from biochemistry and LC-MS assays. under scientist supervision and contribute to summarizing and reporting findings.
- Maintain accurate and detailed records in the electronic laboratory notebook (ELN).