We are seeking a highly innovative Materials Scientist with deep expertise in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules, including PROTACs, RIPTACs, and molecular glues. This role will support the design of advanced solid form screening approaches, amorphous solid dispersion (ASD) formulations, predictive mathematical models. The position is based in Groton, CT (USA).
Role Responsibilities:
- Conduct advanced solid-state characterization of large bRo5 molecules of pharmaceutical relevance.
- Apply novel crystallization techniques to recrystallize bRo5 molecules.
- Support multidisciplinary project teams and collaborate with colleagues to define and implement crystallization, polymorph, salt, and co-crystal screening activities according to project timelines.
- Collaborate with colleagues in Medicinal Chemistry, Formulation and Biopharmaceutics to define and implement screening and characterization strategies consistent with solid form selection for clinical studies.
- Solve scientific problems using contemporary Materials Science experimental techniques.
- Contribute to the development of new scientific approaches and knowledge within the Materials Science organization.
- Ensure contemporaneous and accurate entries are made in the electronic laboratory notebook system according to accepted good practice.