Senior Scientist l, QTAS & ADME Sciences

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise with in vitro models, drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis and ability to spot, ideate and drive cutting-edge science. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working primarily in a laboratory, the position will involve the conduct and contribution to scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to qualify, confirm and evaluate new technologies as well as execute operational activities to support the mechanistic and translational understanding of early and late-stage small molecules to help advance drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

Core responsibilities include:

• Laboratory experimentation in cellular and subcellular models
• Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential
• As needed, liaise with QTAS, discovery biology/pharmacology to generate data and knowledge supporting the build-up of translational, mechanistic models
• Communicate internally and externally on topics related to in vitro drug metabolism
• Keep up to date with emerging literature and science in modeling and in vitro approaches