Front Line Manufacturing Manager - Downstream Bulk Drug Substance - Days

HOW MIGHTYOUDEFY IMAGINATION?

You’veworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills,experience,and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over10 million patientsworldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the AmgenFleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

Front Line Manufacturing Manager - Downstream Bulk Drug Substance - Days

What youwill do

Let’sdo this.Let’schange the world. Amgen is seeking aManager ManufacturingDownstreamto provide frontline leadership supporting the facility expansion program and facility startup. Thisessentialrole will lead a team responsible for manufacturingdownstream purification operations including column packing,columnchromatography, TFF,viralfiltration,viralinactivation, conjugation, and final fillwhile partnering across functions to ensure successful operational readiness, technology transfer, and ramp‑up of manufacturing operations within the new facility.

The Manager will play a critical role supporting the design,build, startup, and operational phases of the facility expansion. The position will initially focus on facility startup and operational readiness activities, transitioning to manufacturing leadership as the facility becomes operational.During this phase of thestartup, you will be expected toworkaMonday – Friday schedule from 8am – 5pm.

This role may require work outside standard business hours, including non‑standard shifts, as needed to support startup, commissioning and qualification (C&Q), and engineering execution. As the business moves from C&Q to manufacturing operations, this essential position willwork on a 12-hour 2-2-3 schedule from 5:45 am to6:15pmsupporting our critical 24/7 manufacturing operations. As Amgen relies upon the regular attendance of all staff members to meet legitimate business needs, the Manager must be able to work assigned 12-hour shift, including during inclement weather, some holidays and requested overtime in support of our operations. 

Responsibilities

• Frontline Leadership:Lead, develop, and coach a manufacturing team; set clear performance expectations; foster a strong culture of safety, quality, and accountability.

• Facility Startup & Operational Readiness:Support design, build, commissioning, qualification (C&Q), staffing, training, and readiness milestones for a new manufacturing facility.

• Manufacturing Operations: Ensure safe, cGMP‑compliant execution; drive performance across safety, quality, schedule, and cost; resolve deviations and operational issues.

• Technology Transfer & Process Implementation:Support transfer and implementation of manufacturing processes; ensure manufacturability, troubleshooting, and continuous improvement.

• Cross‑Functional Collaboration:Partner with Quality, Engineering, NPI, Supply Chain, Validation, and Site Leadership to enable successful startup and ramp‑up.

• Compliance & Inspection Readiness:Maintaininspection readiness and adherence to regulatory and Amgen quality standards.

• Continuous Improvement:Identifyand drive efficiency, reliability, and scalability improvements as operations mature.

• Shift Support:Work non‑standard hours asrequired, transitioning to a 12‑hour 2‑2‑3 dayshift supporting 24/7 operations.

Win 

What we expect from you 

We are all different, yet we all use our unique contributions to serve patients. The biotechnology professional we seek is a manager with these qualifications. 

Basic Qualifications 

• Doctorate degree OR 

• Master’s degree and 3 years of Manufacturing or Operations experience OR 

• Bachelor’s degree and 5 years of Manufacturing or Operations experience OR 

• Associate’s degree and 10 years of Manufacturing or Operations experience OR 

• High school diploma / GED and 12 years of Manufacturing or Operations experience  

• AND Previous managerial experience directly managing people and/or experience leading teams, projects, programs or directing the allocation of resources

Thrive 

What you can expect of us 

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.  

The annual base salary range for this opportunity in the U.S. is provided below.  

In addition to the base salary, Amgen offers a Total Rewards Plan comprising hea