insitro is using machine learning to yield new, clinically actionable insights into critical unmet needs for patients. We aim to "go fast and improve things" across the entire drug development process from platform to pipeline to patients and back again.
The (Senior) Director, Project Team Lead (PTL, also called Asset Team Lead [ATL]) for Clinical Development is an opportunity to directly improve patients' lives by leading cross functional drug development teams from preclinical development candidate (DC) nomination through Phase 1-2 clinical development including proof-of-mechanism (POM) and proof-of-concept (POC). The PTL is accountable for an end-to-end, cross-functional, and effective integration of the therapeutic molecule strategy, timeline, and risk mitigation.
We are devoted to the effort to make clinical trials more helpful for patients and for drug developers. We believe that by focusing on what's best for patients, we can do what's best for drug development at the same time.
You will be at the forefront of designing and implementing innovative, accelerated approaches, and you will have the opportunity to utilize insitro's machine learning expertise to achieve drug development and clinical trial excellence.
You will report directly to the Chief Scientific Officer. This role can be either onsite (3 days per week) in our South San Francisco office or hybrid (~1 week per month) in our office. Additional travel may be needed to relevant medical and health authorities.
This is an excellent opportunity for a seasoned PTL who is passionate about using their skills and experience to accelerate the drug development process and bring better drugs to the patients who can benefit most.
In collaboration with cross-functional teams and working closely with Project and Portfolio Management:
Cross-functional asset/program leadership is the key part of this role
Develop and implement clinical program plans
Develop vision, strategy, and an end-to-end product plan that accounts for early uncertainties in first-in-human clinical development, define prospective, quantifiable endpoints for effective Go No Go decisions, enable the generation of a clinical data package that could support future registrational trial development and commercialization, and ensure there are adequate resources and technical expertise to meet strategic objectives
Identify and manage critical path activities and resources
Identify and manage interdependencies and hand-offs
Identify, classify, proactively mitigate, and document (as appropriate) potential risks and roadblocks, including likelihoods, severities, and key mitigations
Lead contingency planning
Capture and communicate progress; escalate potential delays with proposed solutions
Direct clinical programs through insitro governance to ensure that:
Key drug development functions including preclinical, clinical, technical development/CMC and computational achieve strategic and operational alignment
Programs have adequate resources and technical expertise to meet strategic objectives
Issues are raised, discussed, and resolved in a timely manner
Program/project teams receive insitro Governance decisions in a timely manner
Programs adhere to agreed-upon scope, timelines, resources, and budget
Communication and Culture
Accountable for clear and timely communication about the program throughout insitro such as via: agendas, minutes, all-hands and other communication methods
Responsible for facilitating Core Team meetings and working with Sub-team Leaders to ensure sub-teams and Core Teams are working in alignment on strategic and operational topics.
Present project updates, strategic issues, options, and recommendations to the insitro Governance Committees
Ensure clear and effective communication by each asset/project team by overseeing/reviewing presentations and documents to ensure clarity and effectiveness
Contribute to team culture and positively influence team environment that encourages authentic, clear communication and a "get stuff done" mentality
PhD or MD with 8 (Director) or 12+ (senior director) years (including doctoral or MD experience) of relevant experience and/or advanced education in life sciences, health-related field, or equivalent practical experience. Metabolic disease experience is very nice to have
5+ years of experience in clinical project/asset team leadership or equivalent role in biotechnology and/or pharmaceutical industries, directly as a PTL and in a leadership/management role to deliver therapeutic(s) and diagnostic biomarker(s) in at least one of our key therapeutic areas (metabolic disease, neurology/neurodegeneration, oncology) from FIH through proof-of-concept in the clinic to transition to late development to NDA/BLA submission.
Capable of communicating and collaborating with people of diverse backgrounds and job functions, with a demonstrated a track record of collaborating with diverse stakeholders, including other clinical, translational, computational, and life scientists
Strong interpersonal skills that motivate others to excel and achieve their very best
Passion for providing better medicine to patients in need
Exposure to AI/ML methods is very nice to have
Our target starting salary for successful US-based applicants for this role is $210,000 - $275,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
401(k) plan with employer matching for contributions
Excellent medical, dental, and vision coverage as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
Quarterly budget for books and online courses for self-development
Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
New hire stipend for home office setup
Monthly cell phone & internet stipend
Access to free onsite baristas and daily lunch for employees who are either onsite or hybrid
Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area
insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.
Please be aware of recruitment scams: we never request payments, all recruitment communications are from @insitro.com, and if in doubt, contact us at insitroAbout insitro