Analytical Chemist

• A position is available for a highly skilled analytical chemist or engineer to join in Pharmacokinetics Dynamics and Metabolism New Biological Entities (PDM-NBE) ADME group with deep expertise in antibody ADME and inter-molecular binding

• The lab based role entails training on the state-of-the-art technology for intermolecular interactions and quantification of binding affinity of Biotherapeutics drug to specific proteins in human biological matrices with unwanted immunogenicity

• This position requires strong analytical expertise, with background in engineering, protein biochemistry, immunology or PK as a plus

• The candidate will participate in all phases of laboratory operations including training on the technology, design of reagents, design of binding experiments, the development of sample preparation, assay execution, instrument maintenance, data analysis, summarization and reporting

• We are looking for a scientist passionate about learning and able to quickly apply new skills to the project needs.

Responsibilities-

• Design of protein reagents to be used in binding studies

• Run binding assays under minimal supervision; initiative in method development is expected

• Independent daily operation, calibration, maintenance, and troubleshooting the binding instrument

• Analysis of binding data and derive binding affinity using relevant software

• Work with modeller to build computational immunogenicity model

• Handling of biological samples, specifically human and preclinical serum and tissues

• Summarize work and write reports