Biomarker Scientist

A position is available for a skilled cell biologist/immunologist to join a state-of-the-art cellular biomarker-biomeasures laboratory in PDM, Andover. Expertise in cellular and functional assays using flow cytometry, cell culture and other immunological assays is required. The lab based role entails performing deep immune-phenotyping and phospho-signaling assays of human, mouse and cynomolgus cells, receptor quantification, receptor internalization, and receptor occupancy to support portfolio projects. This position requires deep knowledge of human and mouse immunology, proven expertise in multi-color flow cytometry and biochemical techniques (antibody conjugation to fluorochromes) and a strong background in quantitative cell biology. The candidate will participate in all phases of laboratory operations including sample preparation, hand-on operation of flow cytometers, assay execution, instrument maintenance, data acquisition and reporting.

Responsibilities-

• Prepare and stain cells for receptor quantification, receptor internalization kinetics, immune-phenotyping, functional assays and microscopy

• Run flow assays under minimal supervision; initiative in method development is expected

• Independently carry out daily operation, calibration, maintenance, and trouble-shooting of flow cytometers and time-lapse microscopes

• Help in assay and reagent development, sample preparation and analysis for biomarker discovery using mass cytometry (CyTOF)