Join LGC as a Senior Scientist, Oligonucleotide Chemist, and help drive innovations in oligonucleotide chemistry. Based in our dynamic Innovation Hub team in Petaluma, CA, you will develop and improve methods for synthesis, deprotection, purification, modification, and analysis. Your work will lead to new oligonucleotide products and ensure their smooth transfer into manufacturing. Work alongside a world-class, multidisciplinary team to achieve outstanding results.
- Ensure compliance with safety regulations and Quality Management policies and processes.
- Act as the Technical Lead in Oligonucleotide NPD and custom/co-creation projects.
- Collaborate with multidisciplinary teams to support both IH and Operations project deliverables.
- Act as the technical oligonucleotide chemistry lead, contributing to the development and delivery of new oligonucleotide-based technologies and applications.
- Independently build, project plan, and complete development projects flawlessly.
- Develop synthesis methods to guarantee the effective application of custom/co-creation/NPD oligonucleotides through both automated synthesizers and manual techniques.
- Optimize methods for oligonucleotide modification and conjugation on-column and post-synthesis.
- Develop and refine purification methods for various modified oligonucleotides and conjugates.
- Perform analytical characterization of oligonucleotides using HPLC, mass spectrometry, and other relevant techniques.
- Troubleshoot synthesis, deprotection, and purification processes to resolve manufacturing issues and improve yield and quality.
- Generate documentation packages to support effective control and transfer into manufacturing.
- Act as the subject matter expert after the tech transfer, providing support with chemistry troubleshooting.
- Maintain accurate records of experiments and results in accordance with laboratory protocols.
- Prepare technical reports and present findings to internal and external collaborators, ensuring effective communication at all business and technical levels.