Clinical Laboratory Scientist II

Location: Onsite, Boulder, Colorado, United States

About our Company:

Foresight Diagnostics is a molecular diagnostics company advancing non-invasive cancer detection through highly sensitive, cell-free DNA–based liquid biopsy technologies. Our proprietary methods, originally developed at Stanford University, are designed to enable earlier detection of smaller tumors and support more personalized, effective cancer treatment strategies.

We operate at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), translating rigorous scientific innovation into clinically meaningful solutions. As our organization has grown, we have built robust laboratory operations, cross-functional collaboration, and scalable processes to support clinical development and long-term commercial readiness.

Foresight Diagnostics offers a collaborative, high-accountability work environment where quality, precision, and continuous improvement are core to how we operate. Team members have the opportunity to contribute to impactful programs, work alongside experienced scientific and operational leaders, and grow professionally within a well-resourced and mission-focused organization. Foresight Diagnostics is headquartered in Boulder, Colorado.

About the Role

The Clinical Laboratory Scientist II will be responsible for performing a variety of laboratory procedures involved in end-to-end processing of biological samples to enable successful downstream next-generation sequencing (NGS). Processing will include accessioning and both manual and automated extraction, library preparation, hybrid capture, sequencing and QC steps. Under the guidance of the Director of Clinical Laboratory Operations and the Laboratory Director, you will work collaboratively within the clinical laboratory leveraging your technical knowledge, skills and abilities to ensure efficient and quality results are provided to our clients and patients while also informing/participating in process improvements. This position will report to the Lab Manager.

What You Will Bring

• Bachelor’s or Master's degree in chemical, physical, biological, or clinical laboratory science or medical technology from an accredited institution

  • Education received at a college or university located outside of the United States or United States Territories requires a credentials equivalency evaluation by an approved agency

• Hold a current and active American Society of Clinical Pathology (ASCP) board certification

• Hold current and valid Clinical Laboratory Scientist licensure (Generalist or CGMBS)

• Demonstrate a working knowledge of the general biological principles that govern DNA biology

• Possess a strong foundational understanding of common molecular biology techniques, such as PCR/qPCR, DNA ligation, and DNA extraction

• Working level knowledge or ability to learn use of common molecular biology instruments; Agilent Tapestation/capillary electrophoresis, Qubit, plate readers, thermocyclers and other common laboratory instruments

• Previous experience handling human biological materials is required

• Working knowledge of how to safely operate in a BSL-2 environment is required

• Previous experience handling, processing, and extracting DNA from biological specimens is required

What You Will Do

Technical

• Perform routine and complex diagnostic laboratory testing on patient samples for clinical, biopharma, and academic partnerships.

• Provide technical guidance and oversight to non-licensed personnel for pre-analytical, analytical and post-analytical activities.

• Interpret data and results of all analyses according to set procedures and guidelines.

• Support day to day operations by assisting with data entry, receiving samples and consumables, reagent preparation, sample preparation, temperature recording, laboratory maintenance and documentation.

• Identify and resolve problems that may adversely affect test performance or reporting of test results following the escalation path to clinical leadership as needed.

• Assist with research, translational research, regulated products through the execution of partnership studies and internal/external validation studies.

• Participate as a contributing member of the clinical laboratory by assisting in routine activities, to include but not limited to general upkeep and stocking, SOP author and review, and continuous improvement.

• Proposes assay and process improvements and conducts improvement activities under guidance.

• Demonstrate forward thinking and initiative in work planning and execution of work in order to achieve on-time report delivery.

• Participate in new or revised assay launches giving input on launch logistics as appropriate.

• Participate in work planning initiatives and scheduling.

Quality, Training & Equipment

• Maintaining documentation in compliance with Good Laboratory Practices and Quality Systems.

• Assist with quality control and quality assurance activities. Responsible for reviewing and analyzing the health of laboratory quality metrics in collaboration with clinical leadership.

• Complete initial training and maintain competencies as current and up to date for all trained assays.

• Wear appropriate PPE as required and comply with safety rules and regulations.

• Follow standard operating procedures (SOP).

• Participate in IQ/OQ/PQ for equipment to ensure ability to train team members on proper use and maintenance as appropriate.

• Escalate equipment issues that impact TAT or patient safety.

• Assist, perform, and review instrument correlation studies. Collaborate with operational leadership on equipment analysis for assay expansion or improvement.

• Perform instrument and procedural calibrations and maintenance.

• Advises and drives progress on troubleshooting equipment issues.

• Adhere to the laboratory's quality control policies including document control activities, change management, corrective preventative action.

• May act as trainer in place of designated trainer/training team.

Team

• Cultivate, build and maintain positive and collaborative relationships within teams and cross-functionally.

• Operate as a thought leader and hold cross-functional teams accountable to regulatory, quality, scientific and performance standards to ensure the highest quality for sample integrity.

• Seen as a role model for safety behavior standards and cultural tenets.

• Serves as a leader from the bench, demonstrating consistency in good lab practices.

Working Conditions and Physical Effort

Staff in this role must be able to perform the essential functions of the job with or without a reasonable accommodation. Certain physical activities may be required in order to perform the essential functions of this job. Examples of these requirements include but are not limited to the following:

Compensation and Benefits

This role is offering an hourly wage between $49.28 - 54.09 and is eligible for equity offerings. Foresight offers benefits including paid vacation, sick time, and parental leave (if applicable), alongside medical, dental, vision, life, disability coverage, flexible spending accounts, and a 401k with company match.

You will be working on interesting problems with extremely high impact. We promote the professional development of our employees and will encourage u